北京泛球生物科技有限公司技术目录.doc

Global Biologicals Your Trustable Partner. ABOUT US:G-Bio, depending on the science and technology platform of China Academy of Sciences, Tsinghua University , Peking University and so on, devotes to consultation, technology transfer, patent licensing, technology development, technology incubation, engineering, commissioning and training in biological science and biotechnology, and explores actively new models of commercialization of new technology from lab to industry. G-Bio owns R&D group of specialist and professor from famous university and institute, engineering group of experienced engineers from the industry, and marketing group of international partners. G-Bios technology is very competitive in the world. Additionally G-Bio owns the pilot base and guarantee the transferred technology at least is pilot stage, then is given to the industry. G-Bio also owns HPLC, UV, PCR, automatic fermenter and other laboratory equipments. We not only make and supply products, but also provide fermentation related technology to our clients in fine chemical and pharmaceutical industries. From R&D to production, from analytical to QC, we are ready to serve customers' needs. With strong technical and regulatory expertise, we are looking forward to entering long-term partnership with more clients worldwide.OUR SERVICES:PRODUCT, TECHNOLOGY and CONSULTINGCONSULTING  Market Research Report and Feasibility Study Report  BioTechnology Hunting, Scouting, Consultation and Evaluation  BioTechnology Brokage, BioTechnology Transfer and Patent Licensing  Networking of Biotechnology Transfer TECHNOLOGY TRANSFER  BioTechnology Integration and BioTechnology Commercialization  Supplying highperformance Strain and research materials at Lab Scale or Industrial Scale  Supplying Fermentation Process, Fine Chemical Synthesis Process, Extraction Process and Purification Process  Strain Improvement, Process Optimization ENGINEEING  Contract Research and Contract Manufacturing  Scale up of Process from Lab to Industry  Basic Engineering Design, or Turn-Key Project  Personnel Training, Erection, Commissioning and Technology Support Technology list of APIs, Additives and BiologicsITEMSTECH DATAREMARKS IMMUNOSUPPRESSIVE AGENT他克莫司TacrolimusFinal Titre:800-1000mg/LFermentation time:168hrsRecovery:40%FK506霉酚酸Mycophenoic acidFinal Titre:15g/LFermentation time:264hrsRecovery:70%Intermediatefor MMF 环孢菌素 ACyclosporin AFinal Titre: 10g/LFermentation Time:168hrsRecovery:70%雷帕霉素(西罗莫司)Rapamycin(Sirolimus)Final Titre: 800-1000mg/LFermentation Time:216hrsRecovery:60%Or intermediatefor Zotarolimus, Everolimus and 子囊霉素Ascomycin Final Titre: 600mg/LFermentation Time:216hrsRecovery:60%FK520 Or Intermediate for PimecrolimusANTIBIOTICS阿莫西林AMOXICILLIN By enzyme process头孢氨苄CefalexinBy enzyme process7-ACABy enzyme process7-APABy enzyme process万古霉素Vancomycin Final Titre:9-10g/LFermentation Time: 150hrsRecovery:>70%替考拉宁TeicoplaninFinal Titre:4-5g/LFermentation Time: 150hrsRecovery:>70%达托霉素Daptomycin Final Titre2.0g/LFermentation Time: 200hrsRecovery:>40%Or cubicin 莫匹罗星Mupirocin Final Titre:4-5g/LFermentation Time:60-70hrsRecovery:>75%Pneumocandin B0Final Titre:1.7-2.0g/LFermentation Time: 11-12daysRecovery:>60%Caspofungin 雷莫拉宁RamoplaninFinal Titre:3g/LFermentation Time: 200hrsRecovery:>60%普那霉素（原始霉素）PristinamycinFinal Titre:3-4/LFermentation Time: 150hrsRecovery:>70%克拉维酸（棒酸）Clavulanic AcidFinal Titre:8-10g/LFermentation Time:105hrsRecovery:55%头孢菌素 C Cephalosporin CFinal Titre:40g/LFermentation Time:168hrsRecovery:80%各种头孢类中间体青霉素GPenicillin GFinal Titre:120000g/LFermentation Time:220hrsRecovery:80%红霉素Erythromycin Final Titre:9-10g/LFermentation Time:156hrsRecovery:60%依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体去甲金霉素Demethylchlortetracycline (DMCT)Final Titre:16g/LFermentation Time:200hrsRecovery:75%Intermediate forMiocycline,Tigecylcine 林可霉素（洁霉素）LincomycinFinal Titre:9-10g/LFermentation Time:200hrsRecovery:80-90%克林霉素中间体Clindamycin 杆菌肽BacitracinFinal Titre:1200U/mlFermentation Time:50-60hrsRecovery:95%Zinc Bacitracin forAnimal feed additive那西肽NosiheptideFinal Titre:1700-2000U/mlFermentation Time:50hrsRecovery:95%Animal feed additive两性霉素BAmphotericin BFinal Titre:10000U/mlFermentation Time:130-140hrsRecovery:75%阿维拉霉素（卑霉素）Avilamycin Final Titre:7-8g/LFermentation Time:268hrsRecovery:95%Animal feed additive恩拉霉素Enramycin Final Titre:8-10g/LFermentation Time:260hrsRecovery:95%Animal feed additive卡那霉素Kanamycin Final Titre:25g/LFermentation Time:240hrsRecovery:85%卷曲霉素CapreomycinFinal Titre:11000U/mlFermentation Time:150-160hrsRecovery:75%庆大霉素CGentamicin CFinal Titre:5-6g/LFermentation Time:14daysRecovery:75%庆大霉素BGentamycin BFinal Titre:1000Mmg/LFermentation Time:120-130hrsRecovery:75%异帕米星（Isepamicin）多粘菌素BPolymyxin BFinal titre 2.5 g/lFermentation time 72 hrsRecovery yield 70%粘杆菌素 EPolymyxin E Final titre 18-20g/lFermentation time 96 hrsRecovery yield 75%泰乐菌素Tylosin Final titre 15000 U/lFermentation time 180 hrsRecovery yield 70%巴龙霉素Paromomycin Final titre 8g/lFermentation time170 hrsRecovery yield 70%制霉菌素Nystatin Final titre 300,000IU/mlFermentation time 280 hrsRecovery yield 85%盐霉素Salinomycin Final titre 80g/lFermentation time 268 hrsRecovery yield 90%金霉素Chlortetracycline Final titre 50g/lFermentation time 200 hrsRecovery yield 90%四环素TetracyclineFinal titre 40g/lFermentation time 200 hrsRecovery yield 90%土霉素OxytetracyclineFinal titre 40g/lFermentation time 200 hrsRecovery yield 90%链霉素StreptomycinFinal titre 28,000U/mlFermentation time 200 hrsRecovery yield 80%利福霉素Rifamycin Final titre 30g/lFermentation time 220 hrsRecovery yield 75%黄霉素Flavomycin Final titre 8g/lFermentation time 168 hrsRecovery yield 90%截短侧耳素Pleuromutilin Final titre 14000U/mlFermentation time 300 hrsRecovery yield 80%泰妙菌素Tiamulin大观霉素SpectinomycinFinal titre 7000-10000U/mlFermentation time 130-150 hrsRecovery yield 70%莫能菌素Monensin38000u/mlFinal titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80%妥布霉素TobramycinFinal titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80%安普霉素ApramycinFinal titre 6500-8000U/mlFermentation time 140-170 hrsRecovery yield 70-80%尼可霉素NikkomycinFinal titre 7-8 g/lFermentation time 70 hrsRecovery yield 80%麦角酸Lysergic acidFinal titre 7-8 g/lFermentation time 360 hrsRecovery yield 70%For cabergoline and nicergoline夫西地酸Fusidic Acid Final titre 4-5 g/lFermentation time 200 hrsRecovery yield 40%麦迪霉素MedimycinFinal titre 18g/lFermentation time 200 hrsRecovery yield 75%莫能菌素MonensinFinal Titre:40000U/mlFermentation Time: 300hrsRecovery:95%马杜霉素MaduramicinFinal Titre:612000U/mlFermentation Time: 200hrsRecovery:95%利福霉素Rifamycin Final Titre:25g/LFermentation Time:240hrsRecovery:80%磷霉素Fosfomycin氯霉素Chloramphenicol灰黄霉素GriseofulvinFinal Titre:25g/l螺旋霉素Spiramycin/RovamycinFinal Titre:6000U/mlFermentation Time: 160hrsRecovery:75% 小诺霉素Micronomicin维吉尼亚霉素Virginmycin R&D亮菌甲素（假蜜环菌素）Armillarisin a.美贝霉素Milbemycin2g/L莫西菌素MoxidectinFinal Titre:2000U/mlFermentation Time: 260hrsRecovery:40%道拉菌素DoramectinFinal Titre:1000U/mlFermentation Time: 220hrsRecovery:75%土拉霉素TulathromvcinSemi-chemical米卡芬净micafungin1.5g/L阿尼芬净anidulafungin1.0g/LBio-PESTICIDE阿维菌素AbamectinFinal Titre:5.0g/lFlask:4.8-5.0g/LTime:240hrsRecovery:80%Including its derivatives 多杀菌素Spinosad Final Titre:10-12g/LFermentation Time:200-240hrsRecovery:80%Bio-pesticide 井冈霉素Validamycin Final Titre: 3-4g/LFermentation Time:60-70hrsRecovery:80%春雷霉素KasugamycinFinal Titre: 8000-1000U/mlFermentation Time:192hrsRecovery80%多抗霉素PolyoxinFinal Titre: 5000U/mlFermentation Time:192hrsRecovery：80%脱落酸Abscisic Acid (ABA) Final Titre:1.6g/LFermentation Time:70-72hrsRecovery:60-65%Plant hormoneBiopesticide 赤霉素Gibberellin (GA3)Final Titre:2.5-2.8g/LFermentation Time:150-160hrsRecovery:80%中生霉素zhongshengmycinFinal Titre:10g/LFermentation Time:1200hrsRecovery:80%枯草芽孢杆菌Bacillus subtilisFinal Titre6000U/mlFermentation Time:150-160hrsRecovery:80%苏云金杆菌Bacillus thuringiensisFinal Titre:5500g/mlFermentation Time:150-160hrsRecovery:80%浏阳霉素Liuyangmycin宁南霉素Ningnanmycin链霉素streptomycinFor agricultureANTI-DIABETES米格列醇Miglitol Final Titre:2g/LFermentation Time:70-72hrsRecovery:60-65%Synthesis:90%阿卡波糖Acarbose Final Titre:5-6g/LFermentation Time:130-150hrsRecovery:30-40%伏格列波糖VegliboseChemical synthesisANTI-TUMOR柔红霉素Daunomycin Final Titre:1.5-2.0g/LFermentation Time:168hrsRecovery:>67%For epirubicin, Idarubicin, doxorubicin洋红霉素CarminomycinFinal titre 0.15 g/lFermentation time 168 hrsRecovery yield 65%偏端霉素Distamycin Final titre 2g/lFermentation time 120 hrsRecovery yield 52%博莱霉素BleomycinFinal titre 4g/lFermentation time 168 hrsRecovery yield 70%紫杉醇Paclitaxel Final titre 30mg/lFermentation time 120 hrsRecovery yield 50%丝裂霉素CMitomycin CFinal titre 1000mg/lFermentation time 200 hrsRecovery yield 50%阿霉素DoxorubicinChemical synthesisOr fermentation棕霉素Bruneomycin Final titre 150mg/lFermentation time 144 hrsRecovery yield 60%放线菌素DDactinomycin DChemical synthesis表阿霉素Epirubicin Chemical synthesis伊达比星Idarubicin Chemical synthesis吡柔比星PirarubicinChemical synthesisANTI-CARDIVASCULAR洛伐他汀LovastatinFinal Titre:16g/LFermentation Time:168hrsRecovery:70%美伐他汀CompactinFinal Titre:10g/LFermentation Time:200-220hrs普伐他汀PravastatinFinal Titre: 8.0g/lConversion rate:70%Cycle time: 120-144阿托伐他汀AtorvastatinChemical synthesis瑞舒伐他汀RosuvastatinChemical synthesis辛伐他汀SimvastatinChemical synthesis氟伐他汀FluvastatinChemical synthesisORGANNIC ACIDBiobased chemicals衣康酸Itaconic AcidAcid:>6%Cycle time:40-50hrsConversion:>50%Fermentation data:1.4g/L/hrThe product gets to Pfizer柠檬酸Citric acid莽草酸Shikimic AcidTitre: 25g/LL-乳酸L-Lactic acidAcid:16-18%Conversion rate; 90%丙酮酸Pyruvic acidTitre:55-65g/LConversion rate:55-60%Fermentation time:60hrRecovery:70%长链二元酸Long-chain dicarbxylic acidDCA13-18: 180g/L,Fermentation time:5-6daysBio-based products1，3-丙二醇1,3-propandiol(PDO)Titre: 85g/LConversion rate:60%Productivity:1.2-1.4g/LHChemical 2，3-丁二醇2,3-butandiol 50-65g/LBy product from PDO丁醇Butanol 20g/L甘油GlycerolTitre:160g/lTime:78hrsProductivity:2g/LHMass conversion rate: 48.6%Chemical 丙烯酰胺AcrylamideEnzyme activity: 1 0g/mlAcrylonitrile consumption: 0.75t/tConversion rate: 99.9%Chemical烟酰胺NicotinamideEnzyme activity: 8g/mlNicotinonitrile consumption: 0.85t/tConversion rate: 99.999%Assay: 100%Chemical 羟基乙酸Hydroxyacetic acidEnzyme activity: 0.1g/mlGlycolonitrile consumption: 0.78t/tConversion rate: 99.9%Assay: 99.5% ( pharma grade)Chemical 黄原胶XanthanFinal Titre:5-6g/LFermentation Time:36hrsRecovery:80%琥珀酸（丁二酸）Succinic acid苹果酸Malic acid牛磺酸Taurine乙酸（醋酸）Acetic acid聚羟基脂肪酸Polyhydroxyalkanoates (PHAs)degradable plastics聚乳酸Polylactic acid, PLAVITAMIN AND CAROTENOID维生素B2Vitamin B2Final titre 30g/lFermentation time 72 hrsRecovery yield 80%维生素B12Vitamin B12Final titre 250mg/lTIME:180hrs维生素CVitamin CFinal titre 11-12g/lFermentation time 60 hrsConversion rate; 90%番茄红素LycopeneFinal Titre:>1.0g/L胡萝卜素Beta CaroteneFinal Titre:2.5-3.0g/LFermentation Time:72hrsRecovery:75-80%虾青素Astaxanthin Final Titre:2g/L维生素D2 Vitamin D2Light reaction维生素D3Vitamin D3Light reaction维生素AVitamin Achemical synthesis维生素HVitamin HBy fermentationOr chemical synthesis Biotin HORMONEBiotransformationHormone 雄烯二酮Anostenedione(AD)Final titre 15 g/lFermentation time 200 hrsRecovery yield 75%Intermediate 雄二烯二酮androsta-1,4-diene-3,17-dione(ADD)Final titre 10 g/lFermentation time 200 hrsRecovery yield 72%Intermediate 泼尼松龙Prednisolone Finaltitre>20g/L(Maximum 70g/L)time：5-8 hrsconversion: 97100睾丸素TestosteroneFinal Titre 5g/L去氢甲睾酮Methandrostenolone Final Titre 10g/LPregna 1,4,9,17 acetateFinal Titre 5g/LPregna 1,2,9,21Final Titre 5g/L螺内酯SPIRONOLACTONE 依普利酮EplerenoneANTISPETIC 异抗血酸D-isoascorbate Productivity:18-20g/L那他霉素Natamycin Final Titre:8-10g/LFermentation Time:140-150hrsantiseptic乳酸链球菌素NisinNatural antisepticHEALTHCARE谷胱甘肽Glutathione(GSH)Titre: 4.5g/LBiomass:140g/LFermentation time 72 hrsRecovery yield 45%辅酶Q10Coenzyme Q10Final titre2.5-3.0 g/lFermentation time 96 hrsRecovery yield 60%透明质酸Hyaluronic acid (HA)Final Titre:6-7g/LFermentation Time:20hrsRecovery:90%Best performance is 10g/L花生四烯酸Arachidonic acid (AA)Final titre 9+1.5 g/lFermentation time 192hrsRecovery yield: 65%Food additivesHealthcare S-腺苷甲硫氨酸S-adenosylmethionine (SAMe)二十二碳六烯酸Docosahexaenic Acid(DHA)Final titre 9+1.5 g/lFermentation time 192hrsRecovery yield: 65%N-乙酰葡糖胺Glucosamine (NAG)Others普鲁兰PullulanTitre:60-70g/LConversion:60-70%灵芝多糖PolysaccharideFinal Titre: 1.5g/lCordyceps.sinensis赤藓糖醇Erythritol excipientInstant Active Yeast Food processingYeast extract Food savor麦角固醇ErgosterolFor Vitamin DAlpha-cyclodextrinexcipient Beta- cyclodextrinexcipient肌苷InosineProductivity ：100g/L time： 90小时conversion 35%recovery： 90%鸟苷GuanosineTitre :50-60g/L.time:72小时conversion: 25% recovery: 90% WEIGHT LOSING尼波司他汀LipstatinFinal Titre:8-10g/LFermentation Time:168hrsRecovery:75%Conversion:77.8%Orlistat（奥利司他）Weight losing Enzymes酶制剂Phytase20000U/mlXylaseInquiryCelluaseInquiryAmylaseInquiryProteaseInquiryAcylase,InquiryMany other,Etc Inquiry Penicillin G amidase Amino acidsFolder & food additivesM