2018年ABHD2调控肺泡Ⅱ型上皮细胞凋亡 在慢性阻塞性肺疾病发生中的作用-文档资料.ppt
《2018年ABHD2调控肺泡Ⅱ型上皮细胞凋亡 在慢性阻塞性肺疾病发生中的作用-文档资料.ppt》由会员分享,可在线阅读,更多相关《2018年ABHD2调控肺泡Ⅱ型上皮细胞凋亡 在慢性阻塞性肺疾病发生中的作用-文档资料.ppt(26页珍藏版)》请在三一文库上搜索。
1、COPD - a silent killer,Insidious, diagnosed at late stages,Background,Pathophysiology,Normal vessel,Abormal vessel,Smoking is a major risk factor for COPD Only 10-20% of long-term heavy smokers develop into COPD Part COPD patients with no history of smoking,Environment,Genetics,Clinical characterist
2、ics and prevention direction of COPD :: Interaction of individual genetic susceptibility and environmental factors It is important of susceptible early screening and early intervention in the prevention of chronic obstructive pulmonary disease,The importance of genetic susceptibility to COPD,Recent
3、Advances and trends: Genomic analyses to reveal genetic susceptibility to COPD Regional and Ethnic differences: 1-AT deficiency increase the risk of Caucasian COPD, it is a susceptibility gene for COPD TNF gene mutation associated with Asian COPD such as EPHX1, IL4, IL-10 associated with COPD In add
4、ition to 1-AT, it has not been determined that other genes are susceptibility gene for COPD,Our previous study IL-13 G + 2044A point mutations associated with Caucasian COPD, but no correlation with the Chinese COPD patients (2014, Molecular Biology Reports, Dr. Shoude Jin and colleagues),Key Findin
5、gs: Abhd2 gene deletion in mice naturally develop into emphysema phenotype (2009, BBRC, Dr. Shoude Jin and colleagues) Abhd2 protein is a lipid hydrolase,ABHD2 homologous gene mutations can increase the risk of COPD (2015, Plos one, Dr. Shoude Jin and colleagues ),Yamamura team (our collaborators) K
6、umamoto University, Japan,Abhd2 mouse gene expresses in alveolar type epithelial cells and airway smooth muscle cells,Trapping vector insertion point,Further to verify: Abhd2 expressed in alveolar type cells,Figure. -gal staining pattern P180 common immunofluorescence of 1.Abhd2 knockout mice lung t
7、issue,Our research team: using the Abhd2 knockout mice,Table. the content and relatively of PC, DSPC and protein in lavage fluid and lung tissue homogenates,Phospholipid metabolism in lavage fluid,Increased apoptosis of alveolar type ,Abhd2Gt/Gt,Wild type,Figure . P180 antibody immunohistochemistry
8、of 12-month-old mouse lung slices, the mouse type II alveolar cell count of 6 months and 12 months,The nnumbers of alveolar type cells in every 1000 lung cells,Increased macrophage infiltration in Lung tissue,The nnumbers of macrophages in every 1000 lung cells,12 months,Abhd2Gt/Gt wild type,Figure.
9、 F4 / 80 antibody immunohistochemistry and lung macrophages count comparison in Abhd2Gt / Gt and wild type lung tissue sections,6 months,Figure. The staining of elastic fiber,Wild type Abhd2Gt/Gt,Elastic fibrin reduction,Figure. the stained with HE of lung tissue,Alveolar destruction, expanding and
10、spontaneously formed emphysema phenotype,Figure. Change of protease and anti-protease Factor,Protease /anti-protease imbalance,Figure. The expression of proinflammatory cytokines and apoptosis related genes at the mRNA level,Enhanced expression of inflammatory and apoptosis-related factors,Figure. T
11、he expression levels of oxidation and antioxidant factors,Oxidation and antioxidant factors indifference,Mouse Abhd2 playes an important role in emphysema,The exact mechanism was unclear,But the function of hABHD2 was unclear,Abhd2 features : Abhd2 deficient mice spontaneously emphysema Abhd2 expres
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